Is Hydroquinone Safe to use Long-Term on your Skin? (+ Alternatives) (2024)

Is Hydroquinone Safe to use Long-Term on your Skin? (+ Alternatives) (1)

If you suffer from hyperpigmentation (darkening of the skin) then you are probably looking for any treatment to help lighten up your skin.

If you fit into this situation then you’ve probably at least heard about hydroquinone.

But is using hydroquinone actually safe to use?

In this article, we are going to explore that very question.

If you want the quick version then here it is:

Hydroquinone is an effective skin lightening but it comes with a lot of risks and there are better options available that don’t damage the skin.

So is it safe? Sort of, it depends on how long you use it.

Is it effective? Yes, but there’s also more information there as well.

Let’s dive in to demystify the topic…

What Does Hydroquinone Do?

If you aren’t really sure what hydroquinone is allow me to fill you in.

Hydroquinone is a topical agent that you can put on your skin and it is primarily meant to lighten your skin.

This may sound like a godsend, especially if you have hyperpigmentation, but don’t get sold on it right away. You need to have some more information before you determine if it’s worth using.

Hydroquinone works by reducing the number of melanin in your skin cells.

It does this by inhibiting an enzyme known as tyrosinase which blocks the production of melanin into your cells.

Is Hydroquinone Safe to use Long-Term on your Skin? (+ Alternatives) (2)

Melanin is the natural pigment that your skin cells produce and it is this ingredient which helps determine the color of your skin.

When you go out and tan the sun sends signals to your body to increase the number of melanin in your skin (predominately to protect your cells) and this causes your skin to become tan.

But that’s not why people use hydroquinone!

It’s most often used to treat hyperpigmentation disorders which result in blotchy and uneven skin tones.

Conditions such as acne, melasma, keratosis pilaris, darkening of intimate areas, and the yellowing progress which occurs with aging are all reasons that people want to use skin lighteners.

It’s often prescribed by Doctor’s and dermatologists who want to help patients, but usually because they don’t know about better options.

It’s also particularly attractive if you are on a budget.


Because prescription medications are often much cheaper than more expensive beauty products which contain natural skin lighteners (we will talk more about those later).

Is it Safe?

But, the real question here is whether or not hydroquinone is a viable option for those suffering from hyperpigmentation.

After all, it’s important that something works but it’s also equally important that it doesn’t do more harm than good!

And, while hydroquinone is definitely effective (make no mistake that it will lighten your skin) the side effects of using it may be less than desirable.

First of all:

The melanin in our skin serves as a protective barrier to prevent skin cancer!

If you suddenly suppress the ability of your cells to produce melanin, the very thing that fights off cancer, doesn’t it make sense that this might put your skin at increased risk?

The answer is not exactly clear, but we do know that it probably does increase (slightly) your risk of skin cancer with prolonged use.

In addition, it also frequently causes irritation whenever it is placed on the skin.

Because of this, Doctors frequently don’t recommend that you use it on a consistent or daily basis.

In fact, they like you to only use it for weeks to months at a time and require that you take frequent breaks in between.

Granted, the irritation from hydroquinone may actually be due to the fillers/binders/dyes in the cream itself and not the medication, but it’s still worth discussing.

Part of the problem with getting your skin care products through pharmaceutical companies is that they aren’t really concerned with your skin so much as they are the main ingredient of their medication.

They often put ingredients to help increase absorption and stabilize their medication and these ingredients are often caustic to the skin.

Beauty product lines, on the other hand, usually take great care to try and avoid harmful chemicals inside of their products.

Hydroquinone is also not the best option to use for skin lightening because it can potentially damage and kill off your melanocytes (the cells that produce melanin).

You may want to slow down the production of melanin, but you definitely don’t want to unnecessarily kill off these important cells.

Are There Better Alternatives?

Are you doomed to have pigmented skin for eternity?

The answer is definitely not!

In fact, there are many different options that are available to you that work almost (if not just as good) as hydroquinone and that carry far fewer negative side effects.

The only downside to these products is that they are often much more expensive than other the counter or prescription hydroquinone.

Is Hydroquinone Safe to use Long-Term on your Skin? (+ Alternatives) (3)

But, when you consider that your skin is worth the investment, it makes purchasing these ingredients a no-brainer.

I’ve created a list of skin lighteners that work very well and which are available over the counter (without a prescription) below:

  • Kojic Acid – Kojic acid is another natural ingredient which is formed during the fermentation process of rice. It works to lighten your skin by inhibiting tyrosinase. Kojic acid is often found in soaps, face washes, and other products which means it can be used on your entire body. If you are attempting to lighten more than just your face then kojic acid may be the best option for you.
  • Arbutin – You can think of arbutin as a natural hydroquinone. It works by blocking the same enzyme as hydroquinone but it doesn’t come with all of the irritation that people get with hydroquinone. It’s also not as powerful which means it can be used more frequently and you don’t need to take breaks. If you want to use a product with arbutin in it then I recommend a product such as this.
  • Vitamin C serum – Vitamin C is a naturally occurring vitamin which has skin lightening properties. Using Vitamin C serum (high-quality ones) can help lighten your skin naturally and improve skin texture as well. If anti-aging and taking care of your skin is your primary goal then vitamin C is probably your best bet. I personally love this vitamin C serum.
  • Niacinamide – Niacinamide is vitamin B3 which can be formulated and added to beauty products. Vitamin B3 is incredibly important for your skin and it has been shown to act as a powerful anti-inflammatory. It also helps reduce pigmentation by naturally reducing the aging process. Products which contain niacinamide are often expensive but also benefit your skin in other ways. I recommend looking into products such as this one.

Big Reasons to Avoid using Hydroquinone

Let’s put all of this information together…

While hydroquinone is definitely an effective tool for helping to lighten your skin, there are safer alternatives which work just as good.

I deal with skin on a daily basis and I can tell you that I frequently recommend against using hydroquinone and here’s why:

  • It’s only meant to be used temporarily –
  • It may cause reactive hyperpigmentation when you stop using it
  • It may cause irritation and damage to your skin
  • There are more gentle skin lighteners available

Is It Safe for Children?

We don’t have much information about using hydroquinone for children, but there have been some case reports of kids who consume hydroquinone and suffer from side effects such as seizures.

One of the potential reasons that hydroquinone can cause these issues is that it can sometimes contain mercury which is a known toxic heavy metal.

Do you remember when you have to wear gloves when dealing with mercury in chemistry class?

Sometimes people put mercury in skin lightening agents because it is known to bleach the skin.

The only problem is that mercury is toxic and should absolutely not be handled with your hands or ingested.

Mercury toxicity is the very thing that causes mad hatter disease and causes problems with the brain!

If you are interested in using it for your child then it’s probably best to use something that is safer and won’t cause any damage! When in doubt you can always talk to your pediatrician as well.

Hydroquinone and Pregnancy

Can you use hydroquinone if you are pregnant?

It’s probably not a good idea, but technically it may be safe.

When it comes to pregnancy and putting medications on your skin, you always need to be concerned about how much is being absorbed into your body.

When you put hydroquinone on your skin, about 35 to 45% of the dose that you use will be absorbed and some of that may make it to your baby.

There have been limited studies which test to see if hydroquinone is dangerous so we don’t have really good information.

When in doubt it’s probably best to avoid it in favor of more natural options that don’t carry any potential risk for your baby!

Why would pregnant women want to use hydroquinone?

It turns out that one of the most common hyperpigmentation conditions stems from pregnancy and it’s known as melasma.

Melasma is triggered by excess estrogen stimulation on your melanocytes and excess estrogen happens to occur secondary to pregnancy!

So many women suffering from melasma may be tempted to use hydroquinone to slow down this process.

If you are pregnant and you are suffering from melasma, there are many other options that you can use to try and normalize your skin tone.


Hydroquinone is a skin lightening agent which is effective but not necessarily safe to use, especially for long periods of time.

While it does work, there are various other natural products which can be just as effective and which don’t carry the same potential risks!

Using hydroquinone long term can potentially exacerbate hyperpigmentation disorders and cause local irritation to the skin.

Now I want to hear from you:

Are you using hydroquinone?

Did it work for you?

Did you have any negative side effects?

If so, what did you experience?

Leave your questions or comments below!

Is Hydroquinone Safe to use Long-Term on your Skin? (+ Alternatives) (2024)


Is hydroquinone safe for long-term use? ›

Products containing hydroquinone are available with a prescription. These products are generally safe, but long-term use can cause issues, such as ochronosis.

What is a safer alternative to hydroquinone? ›

The best alternative to Hydroquinone is a product called Cyspera, which effectively reduces pigmentation marks and banishes melasma, leaving a naturally clearer complexion. Its key active ingredient is cysteamine, which is proven to be even more effective than Hydroquinone.

How long can you use hydroquinone on skin? ›

A major key to hydroquinone is short-term use. You can slather it on twice daily for at least six weeks (and no more than six months). After one to three months, you should start to see your hyperpigmentation fade away. At the three-month mark, you should set it aside.

Do dermatologists recommend hydroquinone? ›

Dermatologists often use hydroquinone to treat melasma, a skin condition where dark patches appear on the forehead, cheeks and upper lip.

How harmful is hydroquinone to the skin? ›

Hydroquinone has been found to cause organ-system toxicity and respiratory tract irritation. Organ-system toxicity: Hydroquinone is linked to a skin condition called ochronosis in which the skin (our largest organ) thickens and turns bluish-grey. Exposure of the eye can cause pigmentation and permanent corneal damage.

What happens if you use hydroquinone cream too much? ›

Excessive hydroquinone concentrations may induce toxic or shocking effects on melanocytes, forcing them to regroup and increase their melanin production (resulting in rebound hyperpigmentation). Additionally, high concentrations of hydroquinone may provoke skin inflammation.

What is a natural alternative to hydroquinone? ›

If you're ready to try a new wave of natural skin brighteners, consider the following dermatologist-approved ingredients.
  • Kojic Acid. ...
  • Niacinamide. ...
  • Vitamin C. ...
  • Arbutin. ...
  • Willow Bark Extract. ...
  • Licorice. ...
  • Mulberry Extract. ...
  • Lactic Acid.

What is the natural form of hydroquinone? ›

Arbutin, the b-D-glucopyranoside derivative of hydroquinone, is a naturally occurring plant derived compound found in the dried leaves of a number of different plant species including, bearberry (Arctostaphylos uva-ursi), blueberry, cranberry, and pear trees.

Does hydroquinone cause skin thinning? ›

This is another reason why it's important to stop using your hydroquinone treatment after a while, as directed by your healthcare professional. Giving your skin a break will prevent it from thinning. Alternatively, you can also discuss customising your formula to not include topical steroids with your doctor.

When should I stop using hydroquinone? ›

However, medical guidelines specify that you should stop using hydroquinone if you haven't seen any results after about three months. Your doctor may recommend you try some new products that combine hydroquinone with other ingredients, such as glycolic acid.

Who should not use hydroquinone? ›

You should not use this medicine if you are allergic to hydroquinone or peroxide. Ask a doctor or pharmacist if this medicine is safe to use if you have ever had: liver or kidney disease; asthma or sulfite allergy; or.

Why do people not like hydroquinone? ›

People with dry or sensitive skin may find that using hydroquinone creams results in skin that is even drier or more irritated. In some cases, those side effects can start to fade as the skin begins to adjust to the hydroquinone. In terms of skin tone, hydroquinone creams are best suited to those people who are fairer.

Is hydroquinone bad for the liver? ›

► Hydroquinone may cause a skin allergy. ► Long term exposure may affect the liver and kidneys.

Do dark spots come back after hydroquinone? ›

Hydroquinone-induced inflammation can cause rebound hyperpigmentation and reduced tolerance to hydroquinone itself.

Can you use hydroquinone longer than 3 months? ›

However, most medical providers recommend you use hydroquinone for no longer than 3-6 months, because with prolonged use it can actually make dark patches worse.

How often should you take a break from hydroquinone? ›

After five months, melanocytes should be allowed to stabilize during a two to three month break from hydroquinone. Active melanocytes in the affected areas develop resistance to hydroquinone, after several months which causes the patient's hyperpigmentation in these areas worsens.

Why did they ban hydroquinone? ›

With continued use, hydroquinone and mercury can build up in your body, which may cause harm. The FDA has received reports of serious side effects from the use of hydroquinone, including rashes, facial swelling, and permanent skin discoloration (ochronosis).

How long should you apply hydroquinone? ›

How to use hydroquinone. Hydroquinone is applied topically just to the hyperpigmented skin only, twice daily for 3 months, after which time many patients maintain their improvement by using it twice each week. If there has been no benefit after 3 months of treatment, then the hydroquinone should be stopped.


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